CDK12

Across TCGA patient cohorts, CDK12 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,975 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CDK12-associated proteins across cancer lineages are CSTF1, SUPT6H, and PRPF38A. Each is linked with CDK12 in more than 6 cancer types. Because this analysis shows association rather than direction, both CDK12-to-partner and partner-to-CDK12 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDK12 versus CSTF1 in GBM, with a Pearson correlation of 0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK12→partner) and Y-score (partner→CDK12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CSTF1 →	+0.239	+0.286	<.001	.002	3	7
LSCC	SUPT6H →	+0.316	+0.596	<.001	<.001	3	6
GBM	PRPF38A →	+0.209	+0.355	<.001	<.001	3	5
LSCC	RBM39 →	+0.212	+0.585	<.001	<.001	3	5
LSCC	RFC3 →	+0.360	+0.738	<.001	<.001	3	5
BRCA	CDK12_T692 →	+0.378	+0.845	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,975 associations by consensus.

CDK12 vs CSTF1 — GBM

Explore this scatter interactively →