CDK12

Across TCGA patient cohorts, CDK12 protein abundance is significantly associated with the RNA expression of many other genes, with 12,260 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CDK12-associated genes across cancer lineages are BRCA1, PCLAF, and ATAD5. Each is linked with CDK12 in more than 6 cancer types. Because this analysis shows association rather than direction, both CDK12-to-partner and partner-to-CDK12 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDK12 versus BRCA1 in LSCC, with a Pearson correlation of 0.64.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK12→partner) and Y-score (partner→CDK12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	BRCA1 →	+1.010	+0.313	<.001	<.001	3	7
HNSC	PCLAF →	+0.554	+0.129	<.001	.002	3	7
LSCC	ATAD5 →	+1.053	+0.264	<.001	<.001	3	7
LUAD	HASPIN →	+0.741	+0.253	<.001	<.001	3	7
LUAD	CDC6 →	+1.088	+0.204	<.001	<.001	3	7
LUAD	CDKN3 →	+0.940	+0.201	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,260 associations by consensus.

CDK12 vs BRCA1 — LSCC

Explore this scatter interactively →