CDK12

Across TCGA patient cohorts, CDK12 mutation is significantly associated with the RNA expression of many other genes, with 5,325 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK12-associated genes across cancer lineages are CCNB2, CDKN3, and CEP55. Each is linked with CDK12 in more than 4 cancer types. Because this analysis shows association rather than direction, both CDK12-to-partner and partner-to-CDK12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCNB2 grouped by CDK12-low versus CDK12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK12→partner) and Y-score (partner→CDK12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCNB2 →	+0.635	+2.369	<.001	<.001	3	5
UCEC	CDKN3 →	+0.610	+4.000	<.001	<.001	3	5
UCEC	CEP55 →	+0.682	+2.099	<.001	<.001	3	5
UCEC	BUB1B →	+0.633	+2.379	<.001	<.001	3	4
UCEC	RACGAP1 →	+0.609	+1.868	<.001	<.001	3	4
UCEC	MELK →	+0.764	+2.379	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,325 associations by consensus.

CCNB2 by CDK12 expression — UCEC

Explore this box plot interactively →