CDK12

Across TCGA cell cohorts, CDK12 mutation is significantly associated with the RNA expression of many other genes, with 1,369 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDK12-associated genes across cancer lineages are GFRAL, MRAP, and OR56A1. Each is linked with CDK12 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK12-to-partner and partner-to-CDK12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRAL grouped by CDK12-low versus CDK12-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK12→partner) and Y-score (partner→CDK12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GFRAL →	+0.006	+5.614	<.001	.002	3	2
UPPER_AERODIGESTIVE_TRACT	MRAP →	+0.032	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	OR56A1 →	+0.059	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	OR56A5 →	+0.027	+4.736	.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	PRAMEF4 →	+0.186	+5.357	<.001	.003	3	2
LARGE_INTESTINE	GNPNAT1 →	+0.738	+2.588	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,369 associations by consensus.

GFRAL by CDK12 expression — PANCREAS

Explore this box plot interactively →