CDK11A

Across TCGA patient cohorts, CDK11A mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK11A-associated genes across cancer lineages are Caspase-7-cleavedD198, p62 Lck ligand, and Caspase-8. Each is linked with CDK11A in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK11A-to-partner and partner-to-CDK11A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CDK11A-low versus CDK11A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK11A→partner) and Y-score (partner→CDK11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.782	+3.019	.006	.019	3	2
UCEC	p62 Lck ligand →	+0.438	+3.009	.005	.019	3	1
UCEC	Caspase-8 →	-0.240	-2.459	.048	.019	3	1
BRCA	P-Cadherin →	-0.297	-3.000	.016	.038	1	1
BRCA	DUSP4 →	+0.593	+3.006	.027	.020	1	1
UCEC	Rad50 →	-0.360	-3.584	.002	.002	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Caspase-7-cleavedD198 by CDK11A expression — UCEC

Explore this box plot interactively →