CDK11A

Across TCGA cell cohorts, CDK11A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,519 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CDK11A-associated GO terms across cancer lineages are Regulation of transcription of nucleolar large rRNA by RNA polymerase I, Regulation of mRNA splicing, via spliceosome, and Regulation of double-strand break repair. Each is linked with CDK11A in more than 17 cancer types. Because this analysis shows association rather than direction, both CDK11A-to-partner and partner-to-CDK11A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transcription of nucleolar large rRNA by RNA polymerase I grouped by CDK11A-low versus CDK11A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK11A→partner) and Y-score (partner→CDK11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.174	+1.030	<.001	.002	3	18
BONE	Regulation of mRNA splicing, via spliceosome →	+0.112	+1.248	<.001	<.001	3	16
LIVER	Regulation of double-strand break repair →	+0.071	+0.884	.004	.001	2	17
OESOPHAGUS	Promoter clearance during DNA-templated transcription →	+0.146	+0.875	.001	.003	3	16
OESOPHAGUS	RNA polymerase II promoter clearance →	+0.146	+0.875	.001	.003	3	16
KIDNEY	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.164	+1.081	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,519 associations by consensus.

Regulation of transcription of nucleolar large rRNA by RNA polymerase I by CDK11A expression — BONE

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