CDK11A

Across TCGA cell cohorts, CDK11A mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CDK11A-associated genes across cancer lineages are CCT8L2, TRARG1, and LHCGR. Each is linked with CDK11A in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK11A-to-partner and partner-to-CDK11A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCT8L2 grouped by CDK11A-low versus CDK11A-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK11A→partner) and Y-score (partner→CDK11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CCT8L2 →	+0.059	+4.643	<.001	.005	3	2
LARGE_INTESTINE	TRARG1 →	+0.018	+3.345	<.001	.001	3	2
BLOOD_Lymphoma	LHCGR →	+0.036	+4.350	.001	.005	3	1
BLOOD_Lymphoma	RBMXL3 →	+0.010	+5.247	<.001	.001	3	1
BLOOD_Lymphoma	ADIG →	+0.037	+5.247	<.001	.001	3	1
BLOOD_Lymphoma	DBX2 →	+0.007	+5.169	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

CCT8L2 by CDK11A expression — BLOOD_Lymphoma

Explore this box plot interactively →