Across TCGA patient cohorts, CDK10 mutation is significantly associated with the RNA expression of many other genes, with 281 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK10-associated genes across cancer lineages are RAB28P2, MIR8067, and CYCSP23. Each is linked with CDK10 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDK10-to-partner and partner-to-CDK10 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK10→partner) and Y-score (partner→CDK10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RAB28P2 →	+0.110	+4.302	<.001	.007	3	3
BRCA	MIR8067 →	+0.431	+4.721	<.001	.007	3	2
CESC	CYCSP23 →	+0.072	+4.569	<.001	.005	3	2
KIRP	RN7SL690P →	+0.157	+4.497	<.001	.009	3	2
STAD	MIR15B →	+0.293	+5.678	<.001	.003	3	2
STAD	MORF4L1P6 →	+0.198	+5.274	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 281 associations by consensus.

Exploration

CDK10 survival (RNA) · tumor vs normal (RNA) · all CDK10 data types