Across TCGA patient cohorts, CDK10 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK10-associated genes across cancer lineages are ATM, FoxM1, and FOXO3a_pS318_S321. Each is linked with CDK10 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK10-to-partner and partner-to-CDK10 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK10→partner) and Y-score (partner→CDK10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.698	-3.308	<.001	.009	3	2
UCEC	FoxM1 →	+0.308	+3.469	.008	.002	3	1
UCEC	FOXO3a_pS318_S321 →	-0.123	-2.000	.028	.032	3	1
UCEC	GATA6 →	-0.168	-3.000	.019	.035	3	1
UCEC	INPP4B →	-0.383	-3.321	.008	.009	3	1
UCEC	JNK2 →	+0.291	+2.000	.001	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Exploration

CDK10 survival (RNA) · tumor vs normal (RNA) · all CDK10 data types