Across TCGA cell cohorts, CDK10 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible CDK10-associated genes across cancer lineages are RETN, SRRM4, and DRD3. Each is linked with CDK10 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK10-to-partner and partner-to-CDK10 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK10→partner) and Y-score (partner→CDK10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RETN →	+0.064	+3.807	.003	.003	3	1
OVARY	SRRM4 →	+0.074	+4.113	<.001	.001	3	1
OVARY	DRD3 →	+0.010	+3.405	<.001	.005	3	1
OVARY	RNASE3 →	+0.041	+3.974	<.001	.002	3	1
OVARY	MUCL1 →	+0.246	+3.624	.001	.005	3	1
OVARY	CCL19 →	+0.060	+3.444	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

CDK10 survival (RNA) · tumor vs normal (RNA) · all CDK10 data types