CDK1

Across TCGA patient cohorts, CDK1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK1-associated genes across cancer lineages are EGFR_pY1068, ERK2, and Fibronectin. Each is linked with CDK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK1-to-partner and partner-to-CDK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CDK1-low versus CDK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK1→partner) and Y-score (partner→CDK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.282	-3.169	.040	.020	3	1
UCEC	ERK2 →	+0.298	+3.169	.004	.020	3	1
UCEC	Fibronectin →	-0.384	-3.160	.034	.019	3	1
UCEC	PCNA →	+0.254	+3.169	.032	.020	2	1
UCEC	Tuberin →	+0.335	+2.817	.023	.036	2	1
UCEC	Notch1 →	+0.198	+3.169	.010	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

EGFR_pY1068 by CDK1 expression — UCEC

Explore this box plot interactively →