CDIPT

Across TCGA patient cohorts, CDIPT mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDIPT-associated genes across cancer lineages are eIF4E, FoxM1, and G6PD. Each is linked with CDIPT in more than 1 cancer types. Because this analysis shows association rather than direction, both CDIPT-to-partner and partner-to-CDIPT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CDIPT-low versus CDIPT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDIPT→partner) and Y-score (partner→CDIPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.209	+3.013	.033	.018	3	1
UCEC	FoxM1 →	+0.315	+3.179	.009	.010	3	1
UCEC	G6PD →	-0.351	-3.149	.019	.019	3	1
UCEC	Ku80 →	+0.315	+3.183	.004	.009	3	1
UCEC	MEK1 →	+0.404	+3.321	.017	.010	3	1
UCEC	Notch1 →	+0.218	+3.009	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

eIF4E by CDIPT expression — UCEC

Explore this box plot interactively →