CDHR2

Across TCGA patient cohorts, CDHR2 mutation is significantly associated with the RNA expression of many other genes, with 4,423 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDHR2-associated genes across cancer lineages are ZWINT, SKA1, and TIPIN. Each is linked with CDHR2 in more than 4 cancer types. Because this analysis shows association rather than direction, both CDHR2-to-partner and partner-to-CDHR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZWINT grouped by CDHR2-low versus CDHR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDHR2→partner) and Y-score (partner→CDHR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZWINT →	+0.830	+2.584	<.001	<.001	3	5
UCEC	SKA1 →	+0.856	+2.595	<.001	<.001	3	5
UCEC	TIPIN →	+0.558	+2.606	<.001	<.001	3	5
UCEC	KNL1 →	+0.660	+2.087	<.001	<.001	3	4
UCEC	CKAP2L →	+0.706	+2.098	<.001	<.001	3	4
UCEC	DEPDC1 →	+0.693	+1.885	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,423 associations by consensus.

ZWINT by CDHR2 expression — UCEC

Explore this box plot interactively →