CDHR1

Across TCGA patient cohorts, CDHR1 mutation is significantly associated with the RNA expression of many other genes, with 3,865 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDHR1-associated genes across cancer lineages are MTIF2, KIFC1, and COX15. Each is linked with CDHR1 in more than 4 cancer types. Because this analysis shows association rather than direction, both CDHR1-to-partner and partner-to-CDHR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTIF2 grouped by CDHR1-low versus CDHR1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDHR1→partner) and Y-score (partner→CDHR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MTIF2 →	+0.413	+2.156	.007	<.001	3	5
UCEC	KIFC1 →	+0.560	+1.999	.004	<.001	3	5
SKCM	COX15 →	+0.417	+2.869	.001	.001	3	4
UCEC	PANK4 →	+0.319	+2.140	.001	.002	3	4
UCEC	PGAM1 →	+0.654	+2.091	<.001	<.001	3	4
UCEC	LMNB2 →	+0.619	+1.999	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,865 associations by consensus.

MTIF2 by CDHR1 expression — SKCM

Explore this box plot interactively →