CDHR1

Across TCGA patient cohorts, CDHR1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDHR1-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and FoxM1. Each is linked with CDHR1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CDHR1-to-partner and partner-to-CDHR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CDHR1-low versus CDHR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDHR1→partner) and Y-score (partner→CDHR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.562	-2.986	<.001	<.001	3	4
UCEC	Caspase-7-cleavedD198 →	+0.645	+2.604	<.001	<.001	3	4
STAD	FoxM1 →	+0.382	+2.838	.007	.033	3	3
UCEC	ASNS →	+0.412	+1.847	<.001	.007	3	3
UCEC	Caspase-8 →	-0.241	-4.143	.003	<.001	3	3
UCEC	FOXO3a_pS318_S321 →	-0.089	-1.352	.027	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

ATM by CDHR1 expression — UCEC

Explore this box plot interactively →