CDH7

Across TCGA patient cohorts, CDH7 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDH7-associated genes across cancer lineages are Cyclin-B1, ASNS, and Akt_pT308. Each is linked with CDH7 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDH7-to-partner and partner-to-CDH7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by CDH7-low versus CDH7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH7→partner) and Y-score (partner→CDH7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.601	+2.523	<.001	<.001	3	3
LUAD	ASNS →	+0.378	+2.115	.012	.015	3	3
UCEC	Akt_pT308 →	+0.348	+1.459	.032	.009	3	3
LUSC	14-3-3_beta →	-0.115	-2.418	.022	.018	3	2
LUSC	4E-BP1_pS65 →	+0.182	+2.183	.012	.033	3	2
LUSC	Chk1_pS345 →	+0.116	+2.197	.005	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Cyclin-B1 by CDH7 expression — UCEC

Explore this box plot interactively →