CDH6

Across TCGA cell cohorts, CDH6 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,693 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible CDH6-associated GO terms across cancer lineages are Regulation of positive thymic T cell selection, Neuroligin clustering involved in postsynaptic membrane assembly, and Cellular respiration. Each is linked with CDH6 in more than 7 cancer types. Because this analysis shows association rather than direction, both CDH6-to-partner and partner-to-CDH6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of positive thymic T cell selection grouped by CDH6-low versus CDH6-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH6→partner) and Y-score (partner→CDH6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of positive thymic T cell selection →	-0.221	-2.977	.006	.004	3	8
OVARY	Neuroligin clustering involved in postsynaptic membrane assembly →	+1.155	+3.924	<.001	<.001	3	7
OVARY	Cellular respiration →	+0.067	+2.985	<.001	<.001	3	7
BONE	Protein targeting to vacuole involved in autophagy →	+0.197	+1.978	.005	.007	3	7
BLOOD_Leukemia	Vacuole organization →	+0.031	+0.089	.001	<.001	3	7
SOFT_TISSUE	Indole-containing compound catabolic process →	-0.154	-1.349	.005	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,693 associations by consensus.

Regulation of positive thymic T cell selection by CDH6 expression — LIVER

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