CDH5

Across TCGA patient cohorts, CDH5 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDH5-associated genes across cancer lineages are GAPDH, Caspase-7-cleavedD198, and Cyclin-B1. Each is linked with CDH5 in more than 3 cancer types. Because this analysis shows association rather than direction, both CDH5-to-partner and partner-to-CDH5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by CDH5-low versus CDH5-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH5→partner) and Y-score (partner→CDH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	GAPDH →	+0.503	+3.000	.037	.036	2	4
UCEC	Caspase-7-cleavedD198 →	+0.601	+2.999	.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.643	+3.906	<.001	<.001	3	3
UCEC	EGFR_pY1068 →	-0.239	-1.777	.002	.002	3	2
UCEC	eIF4E →	+0.162	+1.906	.016	.015	3	2
UCEC	ACC_pS79 →	+0.253	+1.424	.022	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

GAPDH by CDH5 expression — BLCA

Explore this box plot interactively →