CDH5

Across TCGA cell cohorts, CDH5 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,559 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CDH5-associated GO terms across cancer lineages are Negative regulation of autophagy, Post-translational protein targeting to endoplasmic reticulum membrane, and Positive regulation of DNA-templated transcription, elongation. Each is linked with CDH5 in more than 5 cancer types. Because this analysis shows association rather than direction, both CDH5-to-partner and partner-to-CDH5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of autophagy grouped by CDH5-low versus CDH5-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH5→partner) and Y-score (partner→CDH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of autophagy →	+0.062	+0.757	<.001	.004	3	5
BONE	Post-translational protein targeting to endoplasmic reticulum membrane →	+0.079	+0.312	.002	.004	3	5
BONE	Positive regulation of DNA-templated transcription, elongation →	+0.093	+0.384	<.001	<.001	3	5
BONE	Positive regulation of transcription elongation by RNA polymerase II →	+0.085	+0.325	<.001	<.001	3	5
BONE	L-methionine metabolic process →	+0.085	+0.320	.007	<.001	3	5
BREAST	Protein N-linked glycosylation →	+0.048	+1.046	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,559 associations by consensus.

Negative regulation of autophagy by CDH5 expression — BREAST

Explore this box plot interactively →