CDH5

Across TCGA cell cohorts, CDH5 mutation is significantly associated with the RNA expression of many other genes, with 108 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDH5-associated genes across cancer lineages are IL17F, LYZL1, and AKAP4. Each is linked with CDH5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDH5-to-partner and partner-to-CDH5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL17F grouped by CDH5-low versus CDH5-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH5→partner) and Y-score (partner→CDH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	IL17F →	+0.032	+3.095	.003	.009	3	1
OVARY	LYZL1 →	+0.042	+3.405	<.001	.005	3	1
OVARY	AKAP4 →	+0.020	+3.865	.001	.001	3	1
OVARY	SPATA48 →	+0.006	+3.807	<.001	.009	3	1
OVARY	OR2D2 →	+0.020	+4.260	.007	<.001	3	1
OVARY	PATE1 →	+0.043	+3.974	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 108 associations by consensus.

IL17F by CDH5 expression — OVARY

Explore this box plot interactively →