CDH24

Across TCGA patient cohorts, CDH24 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDH24-associated genes across cancer lineages are Caspase-7-cleavedD198, MEK1, and MSH6. Each is linked with CDH24 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDH24-to-partner and partner-to-CDH24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CDH24-low versus CDH24-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH24→partner) and Y-score (partner→CDH24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.719	+3.169	.004	.018	3	3
UCEC	MEK1 →	+0.448	+3.459	.003	.005	3	2
UCEC	MSH6 →	-0.372	-1.700	.007	.044	3	1
UCEC	NDRG1_pT346 →	+0.436	+1.700	.036	.044	3	1
UCEC	NF2 →	+0.181	+3.000	.048	.036	3	1
UCEC	p62 Lck ligand →	+0.319	+2.469	.021	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Caspase-7-cleavedD198 by CDH24 expression — UCEC

Explore this box plot interactively →