CDH22

Across TCGA patient cohorts, CDH22 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDH22-associated genes across cancer lineages are PCNA, ASNS, and Cyclin-B1. Each is linked with CDH22 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDH22-to-partner and partner-to-CDH22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by CDH22-low versus CDH22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH22→partner) and Y-score (partner→CDH22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.248	+1.906	.004	.016	3	3
UCEC	ASNS →	+0.435	+3.321	.002	.009	3	3
SKCM	Cyclin-B1 →	+0.741	+3.334	<.001	.005	3	3
SKCM	STAT3_pY705 →	-0.303	-2.000	.012	.031	3	3
BLCA	Rb_pS807_S811 →	+0.522	+2.999	.023	.035	3	2
UCEC	A-Raf_pS299 →	-0.131	-2.321	.006	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

PCNA by CDH22 expression — UCEC

Explore this box plot interactively →