CDH22

Across TCGA cell cohorts, CDH22 mutation is significantly associated with the RNA expression of many other genes, with 396 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDH22-associated genes across cancer lineages are IFNA2, MAP2K4, and TMEM272. Each is linked with CDH22 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDH22-to-partner and partner-to-CDH22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA2 grouped by CDH22-low versus CDH22-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH22→partner) and Y-score (partner→CDH22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	IFNA2 →	+0.020	+5.807	<.001	.001	3	2
LARGE_INTESTINE	MAP2K4 →	+0.792	+2.850	.001	<.001	3	2
URINARY_TRACT	TMEM272 →	+0.022	+3.584	.004	.009	3	1
OESOPHAGUS	BMP15 →	+0.030	+4.906	<.001	.006	3	1
OESOPHAGUS	NLRP8 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	KLHL34 →	+0.013	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 396 associations by consensus.

IFNA2 by CDH22 expression — OVARY

Explore this box plot interactively →