CDH2

Across TCGA patient cohorts, CDH2 mutation is significantly associated with the RNA expression of many other genes, with 4,721 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDH2-associated genes across cancer lineages are MRPL39, FAM83D, and PRC1. Each is linked with CDH2 in more than 4 cancer types. Because this analysis shows association rather than direction, both CDH2-to-partner and partner-to-CDH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL39 grouped by CDH2-low versus CDH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH2→partner) and Y-score (partner→CDH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPL39 →	+0.362	+2.052	<.001	.001	3	5
LUAD	FAM83D →	+0.738	+1.777	.004	.008	3	4
LUAD	PRC1 →	+0.720	+2.169	.001	.003	3	4
LUAD	TAFA5 →	-0.739	-3.798	.002	<.001	3	4
COAD	ELP5 →	+0.331	+3.127	.001	<.001	3	4
UCEC	OIP5 →	+0.577	+2.137	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,721 associations by consensus.

MRPL39 by CDH2 expression — UCEC

Explore this box plot interactively →