CDH2

Across TCGA cell cohorts, CDH2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,375 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CDH2-associated GO terms across cancer lineages are Neuroligin clustering involved in postsynaptic membrane assembly, Positive regulation of stress fiber assembly, and Establishment of Golgi localization. Each is linked with CDH2 in more than 18 cancer types. Because this analysis shows association rather than direction, both CDH2-to-partner and partner-to-CDH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Neuroligin clustering involved in postsynaptic membrane assembly grouped by CDH2-low versus CDH2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH2→partner) and Y-score (partner→CDH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Neuroligin clustering involved in postsynaptic membrane assembly →	+1.963	+3.525	<.001	<.001	3	19
BONE	Positive regulation of stress fiber assembly →	+0.184	+4.040	<.001	<.001	3	12
BONE	Establishment of Golgi localization →	+0.124	+3.354	<.001	<.001	3	12
BREAST	Positive regulation of extracellular matrix organization →	+0.142	+2.898	.001	<.001	3	11
LUNG_NSCLC_LUSC	AV node cell action potential →	-1.362	-3.215	.001	.001	3	11
LUNG_NSCLC_LUSC	AV node cell to bundle of His cell signaling →	-1.362	-3.215	.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,375 associations by consensus.

Neuroligin clustering involved in postsynaptic membrane assembly by CDH2 expression — PANCREAS

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