CDH2

Across TCGA cell cohorts, CDH2 mutation is significantly associated with the RNA expression of many other genes, with 327 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDH2-associated genes across cancer lineages are MYL1, KRTAP4-12, and GPR63. Each is linked with CDH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDH2-to-partner and partner-to-CDH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYL1 grouped by CDH2-low versus CDH2-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH2→partner) and Y-score (partner→CDH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MYL1 →	+0.114	+3.963	<.001	.003	3	2
BLOOD_Lymphoma	KRTAP4-12 →	+0.042	+3.584	.001	.004	3	2
LARGE_INTESTINE	GPR63 →	+0.823	+3.743	<.001	<.001	3	2
LARGE_INTESTINE	PPIL6 →	+1.067	+3.743	<.001	<.001	3	2
LARGE_INTESTINE	TMEM35B →	+0.477	+3.459	.003	.001	3	2
UPPER_AERODIGESTIVE_TRACT	FAM236A →	+0.120	+5.357	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 327 associations by consensus.

MYL1 by CDH2 expression — BREAST

Explore this box plot interactively →