CDH13

Across TCGA patient cohorts, CDH13 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDH13-associated genes across cancer lineages are FOXO3a_pS318_S321, p38-MAPK_pT180_Y182, and Rad50. Each is linked with CDH13 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDH13-to-partner and partner-to-CDH13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by CDH13-low versus CDH13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH13→partner) and Y-score (partner→CDH13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.110	-1.279	.002	.021	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.442	-1.227	<.001	.015	3	3
UCEC	Rad50 →	-0.189	-1.637	.007	.001	3	3
UCEC	4E-BP1 →	+0.246	+1.877	.002	.004	3	3
UCEC	eEF2 →	+0.281	+1.241	.007	.015	3	2
UCEC	Notch1 →	+0.137	+1.672	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

FOXO3a_pS318_S321 by CDH13 expression — UCEC

Explore this box plot interactively →