CDH12

Across TCGA pan-cancer cohorts, CDH12 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CDH12 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CDH12 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CDH12 expression acts as an unfavorable survival marker, although some lineages such as LUSC show a favorable association.

COAD, DLBC, and BLCA are the cancer types where CDH12 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	IV	0.082	0.659	<.001	22	view →
DLBC	DFS	Median	II,III,IV	0.065	0.829	<.001	18	view →
BLCA	DFS	Median	All	0.155	0.497	.034	6	view →
ESCA	OS	Median	All	0.597	0.870	.019	6	view →
LUSC	OS	Median	II,III,IV	0.785	0.393	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CDH12–COAD (OS)

Open the COAD breakdown →