CDH12

Across TCGA patient cohorts, CDH12 mutation is significantly associated with the RNA expression of many other genes, with 6,713 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDH12-associated genes across cancer lineages are MIS18A, TRABD, and UBE2T. Each is linked with CDH12 in more than 5 cancer types. Because this analysis shows association rather than direction, both CDH12-to-partner and partner-to-CDH12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIS18A grouped by CDH12-low versus CDH12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH12→partner) and Y-score (partner→CDH12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIS18A →	+0.382	+1.197	.001	.002	3	5
UCEC	TRABD →	+0.413	+1.482	<.001	<.001	3	5
LUAD	UBE2T →	+0.559	+1.311	.001	.002	3	5
STAD	FH →	+0.466	+2.259	<.001	.005	3	5
UCEC	CCNB1 →	+0.634	+1.725	<.001	<.001	3	5
LUAD	ALKBH2 →	+0.292	+1.182	.003	.007	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,713 associations by consensus.

MIS18A by CDH12 expression — UCEC

Explore this box plot interactively →