CDH12

Across TCGA cell cohorts, CDH12 mutation is significantly associated with the RNA expression of many other genes, with 157 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CDH12-associated genes across cancer lineages are GHRHR, PCARE, and LHFPL1. Each is linked with CDH12 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDH12-to-partner and partner-to-CDH12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHRHR grouped by CDH12-low versus CDH12-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH12→partner) and Y-score (partner→CDH12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GHRHR →	+0.339	+3.934	<.001	.002	3	2
BLOOD_Lymphoma	PCARE →	+0.023	+3.353	<.001	.002	3	2
BLOOD_Lymphoma	LHFPL1 →	+0.324	+4.082	.001	<.001	3	2
SKIN	C9orf92 →	+0.075	+2.610	<.001	.001	3	2
BLOOD_Leukemia	OR10G2 →	+0.698	+2.644	<.001	.008	3	2
BLOOD_Lymphoma	RBP2 →	+0.077	+4.121	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 157 associations by consensus.

GHRHR by CDH12 expression — BLOOD_Lymphoma

Explore this box plot interactively →