CDH11

Across TCGA patient cohorts, CDH11 mutation is significantly associated with the RNA expression of many other genes, with 8,831 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDH11-associated genes across cancer lineages are SAPCD2, WDR5, and SCUBE2. Each is linked with CDH11 in more than 4 cancer types. Because this analysis shows association rather than direction, both CDH11-to-partner and partner-to-CDH11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SAPCD2 grouped by CDH11-low versus CDH11-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH11→partner) and Y-score (partner→CDH11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SAPCD2 →	+0.852	+2.807	.001	.003	3	5
UCEC	WDR5 →	+0.502	+2.324	<.001	<.001	3	5
LUAD	SCUBE2 →	-0.933	-1.807	.001	.004	3	5
STAD	GPR3 →	+0.658	+3.725	<.001	<.001	3	5
UCEC	MCAT →	+0.406	+1.469	<.001	<.001	3	5
UCEC	TLE6 →	+0.502	+1.573	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,831 associations by consensus.

SAPCD2 by CDH11 expression — HNSC

Explore this box plot interactively →