CDH11

Across TCGA patient cohorts, CDH11 mutation is significantly associated with the total protein of many other genes, with 85 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDH11-associated genes across cancer lineages are c-Kit, eIF4E, and cIAP. Each is linked with CDH11 in more than 4 cancer types. Because this analysis shows association rather than direction, both CDH11-to-partner and partner-to-CDH11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Kit grouped by CDH11-low versus CDH11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH11→partner) and Y-score (partner→CDH11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Kit →	-0.163	-1.544	.008	<.001	3	5
STAD	eIF4E →	+0.173	+1.700	.012	.042	3	4
LUSC	cIAP →	+0.196	+2.009	<.001	.018	3	4
LUSC	MYH11 →	-1.170	-1.990	.002	.031	3	3
LUSC	Cyclin-E1 →	+0.240	+2.009	.036	.018	3	3
BLCA	HER2 →	+0.533	+2.999	.037	.035	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 85 associations by consensus.

c-Kit by CDH11 expression — UCEC

Explore this box plot interactively →