CDH10

Across TCGA patient cohorts, CDH10 mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDH10-associated genes across cancer lineages are MIG-6, Src_pY416, and MEK1. Each is linked with CDH10 in more than 4 cancer types. Because this analysis shows association rather than direction, both CDH10-to-partner and partner-to-CDH10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIG-6 grouped by CDH10-low versus CDH10-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH10→partner) and Y-score (partner→CDH10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIG-6 →	+0.105	+0.951	<.001	.049	3	5
LUSC	Src_pY416 →	-0.193	-1.247	.021	.033	3	4
UCEC	MEK1 →	+0.386	+1.662	<.001	<.001	3	4
LUAD	FoxM1 →	+0.232	+1.214	<.001	.014	3	3
UCEC	PDCD4 →	-0.346	-1.652	.004	.004	3	3
LUAD	Bcl-2 →	-0.216	-1.813	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

MIG-6 by CDH10 expression — LUSC

Explore this box plot interactively →