CDH1

Across TCGA patient cohorts, CDH1 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDH1-associated genes across cancer lineages are Bax, E-Cadherin, and Bcl-2. Each is linked with CDH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDH1-to-partner and partner-to-CDH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bax grouped by CDH1-low versus CDH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH1→partner) and Y-score (partner→CDH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bax →	+0.246	+1.893	<.001	<.001	3	3
BRCA	E-Cadherin →	-1.275	-2.584	<.001	<.001	3	3
STAD	Bcl-2 →	+0.220	+2.475	.008	.009	3	3
UCEC	JNK2 →	+0.178	+1.415	.003	.010	3	2
UCEC	PCNA →	+0.232	+1.893	<.001	<.001	3	2
BRCA	beta-Catenin →	-0.606	-2.266	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

Bax by CDH1 expression — UCEC

Explore this box plot interactively →