CDC73

Across TCGA pan-cancer cohorts, CDC73 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CDC73 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CDC73 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CDC73 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where CDC73 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.828	0.937	.011	10	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	9	view →
LSCC	DFS	Quartile	II,III,IV	0.872	0.492	.013	5	view →
CCRCC	OS	Tertile	All	0.902	1.000	.035	3	view →
LUAD	DFS	Tertile	III,IV	0.780	0.356	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CDC73–HNSC (OS)

Open the HNSC breakdown →