CDC73

Across TCGA patient cohorts, CDC73 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,401 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible CDC73-associated proteins across cancer lineages are RO60, GATAD2B, and ANP32E. Each is linked with CDC73 in more than 6 cancer types. Because this analysis shows association rather than direction, both CDC73-to-partner and partner-to-CDC73 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDC73 versus RO60 in BRCA, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC73→partner) and Y-score (partner→CDC73) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RO60 →	+0.362	+0.639	<.001	<.001	3	7
UCEC	GATAD2B →	+0.280	+0.613	<.001	<.001	3	7
LUAD	ANP32E →	+0.507	+0.365	<.001	<.001	3	7
UCEC	BROX →	+0.403	+0.563	<.001	<.001	3	6
HNSC	C1orf35 →	+0.472	+0.844	<.001	<.001	3	6
LSCC	DHX9 →	+0.215	+0.351	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,401 associations by consensus.

CDC73 vs RO60 — BRCA

Explore this scatter interactively →