CDC73

Across TCGA patient cohorts, CDC73 mutation is significantly associated with the RNA expression of many other genes, with 3,044 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC73-associated genes across cancer lineages are RNA5SP90, MTCO2P23, and RNA5SP197. Each is linked with CDC73 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDC73-to-partner and partner-to-CDC73 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP90 grouped by CDC73-low versus CDC73-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC73→partner) and Y-score (partner→CDC73) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	RNA5SP90 →	+0.494	+5.602	<.001	.004	3	3
COAD	MTCO2P23 →	+0.208	+4.498	<.001	<.001	3	3
CESC	RNA5SP197 →	+0.321	+3.934	<.001	.005	3	2
LUAD	RFPL4AL1 →	+0.083	+5.415	<.001	<.001	3	2
COAD	RNA5SP191 →	+0.797	+3.258	.009	.002	3	2
COAD	RNY1P10 →	+0.734	+3.372	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,044 associations by consensus.

RNA5SP90 by CDC73 expression — LGG

Explore this box plot interactively →