CDC73

Across TCGA patient cohorts, CDC73 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC73-associated genes across cancer lineages are eEF2, GAPDH, and PCNA. Each is linked with CDC73 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDC73-to-partner and partner-to-CDC73 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CDC73-low versus CDC73-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC73→partner) and Y-score (partner→CDC73) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eEF2 →	+0.463	+3.008	.002	.019	3	2
COAD	GAPDH →	+0.675	+3.008	.010	.019	2	3
COAD	PCNA →	+0.354	+3.008	.005	.019	3	2
UCEC	Notch1 →	+0.094	+1.263	.029	.019	3	2
UCEC	p62 Lck ligand →	+0.296	+2.321	.002	.005	3	2
UCEC	p70-S6K_pT389 →	-0.122	-1.700	.035	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

eEF2 by CDC73 expression — COAD

Explore this box plot interactively →