CDC73

Across TCGA cell cohorts, CDC73 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,598 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CDC73-associated GO terms across cancer lineages are Positive regulation of mRNA processing, Positive regulation of mRNA 3'-end processing, and mRNA transport. Each is linked with CDC73 in more than 19 cancer types. Because this analysis shows association rather than direction, both CDC73-to-partner and partner-to-CDC73 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mRNA processing grouped by CDC73-low versus CDC73-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC73→partner) and Y-score (partner→CDC73) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Positive regulation of mRNA processing →	+0.136	+0.958	<.001	<.001	3	20
SKIN	Positive regulation of mRNA 3'-end processing →	+0.127	+0.727	<.001	<.001	3	16
BLOOD_Myeloma	mRNA transport →	+0.087	+1.077	.003	.003	3	15
SOFT_TISSUE	Establishment of RNA localization →	+0.080	+0.833	.001	.004	3	15
LARGE_INTESTINE	Regulation of formation of translation preinitiation complex →	+0.078	+0.792	<.001	<.001	3	15
LARGE_INTESTINE	Negative regulation of formation of translation preinitiation complex →	+0.078	+0.792	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,598 associations by consensus.

Positive regulation of mRNA processing by CDC73 expression — LIVER

Explore this box plot interactively →