CDC73

Across TCGA cell cohorts, CDC73 mutation is significantly associated with the RNA expression of many other genes, with 251 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDC73-associated genes across cancer lineages are CBY1, SH3GL2, and MINPP1. Each is linked with CDC73 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC73-to-partner and partner-to-CDC73 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBY1 grouped by CDC73-low versus CDC73-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC73→partner) and Y-score (partner→CDC73) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CBY1 →	+0.747	+3.299	<.001	.004	3	1
LARGE_INTESTINE	SH3GL2 →	+1.935	+3.667	<.001	<.001	3	1
LARGE_INTESTINE	MINPP1 →	+0.716	+3.299	<.001	.004	3	1
LARGE_INTESTINE	TRIM37 →	+0.641	+3.212	.004	.006	3	1
LARGE_INTESTINE	GPR63 →	+1.031	+3.212	<.001	.006	3	1
LARGE_INTESTINE	WRAP73 →	+0.610	+3.212	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 251 associations by consensus.

CBY1 by CDC73 expression — LARGE_INTESTINE

Explore this box plot interactively →