CDC7

Across TCGA cell cohorts, CDC7 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,319 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CDC7-associated GO terms across cancer lineages are DNA replication, DNA-templated DNA replication, and Sister chromatid cohesion. Each is linked with CDC7 in more than 19 cancer types. Because this analysis shows association rather than direction, both CDC7-to-partner and partner-to-CDC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication grouped by CDC7-low versus CDC7-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC7→partner) and Y-score (partner→CDC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA replication →	+0.133	+2.018	<.001	<.001	3	20
BLOOD_Myeloma	DNA-templated DNA replication →	+0.139	+1.477	<.001	<.001	3	20
OESOPHAGUS	Sister chromatid cohesion →	+0.111	+0.936	<.001	<.001	3	20
BLOOD_Myeloma	Double-strand break repair via homologous recombination →	+0.094	+1.893	<.001	<.001	3	20
PANCREAS	Recombinational repair →	+0.100	+1.363	<.001	<.001	3	20
BLOOD_Myeloma	DNA strand elongation →	+0.171	+1.501	<.001	.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,319 associations by consensus.

DNA replication by CDC7 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →