CDC7

Across TCGA cell cohorts, CDC7 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDC7-associated genes across cancer lineages are OR52K1, PCARE, and C8orf86. Each is linked with CDC7 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC7-to-partner and partner-to-CDC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52K1 grouped by CDC7-low versus CDC7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC7→partner) and Y-score (partner→CDC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR52K1 →	+0.010	+3.217	<.001	.006	3	2
BLOOD_Lymphoma	PCARE →	+0.038	+4.523	<.001	.004	3	1
BLOOD_Lymphoma	C8orf86 →	+0.017	+4.191	.001	.007	3	1
LUNG_NSCLC_LUAD	OR2T10 →	+0.029	+5.228	<.001	.005	3	1
UPPER_AERODIGESTIVE_TRACT	BPIFB3 →	+0.015	+4.357	<.001	.006	3	1
STOMACH	CHRNB3 →	+0.013	+5.285	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

OR52K1 by CDC7 expression — LARGE_INTESTINE

Explore this box plot interactively →