CDC6

Across TCGA patient cohorts, CDC6 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC6-associated genes across cancer lineages are ATM, MSH2, and p62 Lck ligand. Each is linked with CDC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC6-to-partner and partner-to-CDC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CDC6-low versus CDC6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC6→partner) and Y-score (partner→CDC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.557	-2.000	.006	.032	3	2
UCEC	MSH2 →	-0.388	-2.973	<.001	.035	3	1
UCEC	p62 Lck ligand →	+0.392	+2.000	.007	.032	3	1
UCEC	PCNA →	+0.283	+2.000	.003	.032	3	1
UCEC	Rab25 →	-0.446	-3.321	.002	.009	3	1
UCEC	TFRC →	+0.539	+2.000	.024	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ATM by CDC6 expression — UCEC

Explore this box plot interactively →