CDC6

Across TCGA cell cohorts, CDC6 mutation is significantly associated with the RNA expression of many other genes, with 58 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CDC6-associated genes across cancer lineages are MAGEB4, OPN4, and ZNF831. Each is linked with CDC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC6-to-partner and partner-to-CDC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by CDC6-low versus CDC6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC6→partner) and Y-score (partner→CDC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.022	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OPN4 →	+0.013	+4.930	.007	.001	3	1
LARGE_INTESTINE	ZNF831 →	+0.018	+4.273	<.001	.006	3	1
LARGE_INTESTINE	STRA8 →	+0.161	+4.415	<.001	.007	3	1
LARGE_INTESTINE	MSGN1 →	+0.089	+4.930	<.001	.001	3	1
LARGE_INTESTINE	ZNF804B →	+0.016	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

MAGEB4 by CDC6 expression — LARGE_INTESTINE

Explore this box plot interactively →