CDC42EP5

Across TCGA pan-cancer cohorts, CDC42EP5 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CDC42EP5 data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CDC42EP5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CDC42EP5 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

LSCC, UCEC, and PDAC are the cancer types where CDC42EP5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.367	0.865	.001	32	view →
UCEC	OS	Tertile	II,III,IV	0.433	1.000	.004	16	view →
PDAC	OS	Tertile	II,III,IV	1.000	0.665	.001	11	view →
CCRCC	DFS	Tertile	III,IV	0.824	0.271	.003	6	view →
LUAD	OS	Tertile	All	0.861	0.701	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CDC42EP5–LSCC (DFS)

Open the LSCC breakdown →