CDC42EP4

Across TCGA pan-cancer cohorts, CDC42EP4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CDC42EP4 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CDC42EP4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CDC42EP4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where CDC42EP4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.782	0.974	.002	42	view →
CCRCC	OS	Median	IV	0.785	0.123	.009	17	view →
PDAC	DFS	Quartile	All	0.525	0.203	.019	9	view →
GBM	OS	Tertile	All	0.240	0.573	.018	4	view →
LUAD	OS	Median	All	0.883	0.783	.030	4	view →
LSCC	DFS	Tertile	All	0.753	0.931	.041	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CDC42EP4–HNSC (OS)

Open the HNSC breakdown →