CDC42EP4

Across TCGA patient cohorts, CDC42EP4 mutation is significantly associated with the RNA expression of many other genes, with 579 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC42EP4-associated genes across cancer lineages are MIR4718, SNORD116-23, and C2CD4D. Each is linked with CDC42EP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC42EP4-to-partner and partner-to-CDC42EP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4718 grouped by CDC42EP4-low versus CDC42EP4-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC42EP4→partner) and Y-score (partner→CDC42EP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR4718 →	+0.452	+5.936	<.001	.001	3	2
UCEC	SNORD116-23 →	+0.474	+2.039	.007	.006	3	2
UCEC	C2CD4D →	-0.675	-3.419	<.001	.005	3	2
UCEC	MON1A →	+0.483	+3.378	<.001	.004	3	2
SKCM	DMAC1P1 →	+0.258	+2.277	<.001	.009	3	2
SKCM	L3MBTL4 →	-1.053	-3.309	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 579 associations by consensus.

MIR4718 by CDC42EP4 expression — HNSC

Explore this box plot interactively →