CDC42EP4

Across TCGA patient cohorts, CDC42EP4 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDC42EP4-associated genes across cancer lineages are MIG-6, p70-S6K, and eIF4E. Each is linked with CDC42EP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC42EP4-to-partner and partner-to-CDC42EP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIG-6 grouped by CDC42EP4-low versus CDC42EP4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC42EP4→partner) and Y-score (partner→CDC42EP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIG-6 →	+0.264	+2.824	.006	.036	3	2
UCEC	p70-S6K →	+0.273	+2.999	.003	.035	3	2
UCEC	eIF4E →	+0.214	+3.584	.035	.002	3	1
UCEC	JNK_pT183_Y185 →	-0.197	-2.446	.015	.020	3	1
UCEC	MEK1 →	+0.401	+2.459	.023	.020	3	1
UCEC	mTOR_pS2448 →	-0.187	-2.980	.009	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

MIG-6 by CDC42EP4 expression — SKCM

Explore this box plot interactively →