CDC42EP4

Across TCGA cell cohorts, CDC42EP4 mutation is significantly associated with the RNA expression of many other genes, with 307 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDC42EP4-associated genes across cancer lineages are OR6C68, HHLA1, and CNGA2. Each is linked with CDC42EP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDC42EP4-to-partner and partner-to-CDC42EP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6C68 grouped by CDC42EP4-low versus CDC42EP4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDC42EP4→partner) and Y-score (partner→CDC42EP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR6C68 →	+0.042	+5.415	<.001	.004	3	1
BLOOD_Leukemia	HHLA1 →	+0.006	+4.551	.002	.004	3	1
BLOOD_Leukemia	CNGA2 →	+0.074	+4.539	<.001	.007	3	1
BLOOD_Leukemia	NPSR1 →	+0.028	+4.152	<.001	.009	3	1
BLOOD_Leukemia	IQCJ →	+0.662	+4.276	<.001	.007	3	1
LARGE_INTESTINE	DEPDC5 →	+0.658	+3.364	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 307 associations by consensus.

OR6C68 by CDC42EP4 expression — SKIN

Explore this box plot interactively →