CDC42EP3

Across TCGA pan-cancer cohorts, CDC42EP3 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CDC42EP3’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where CDC42EP3 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CDC42EP3 is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

LUAD, HNSC, and LSCC are the cancer types where CDC42EP3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDC42EP3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	−0.426	<.001	9	view →
HNSC	Male	IV	+0.657	<.001	8	view →
LSCC	Male	III,IV	−0.323	<.001	6	view →
PDAC	All	All	+0.334	<.001	5	view →
CCRCC	All	All	−0.278	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CDC42EP3–LUAD

Open the LUAD breakdown →